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    OVERVIEW

    Heparin and heparan sulfate (HS) glycosaminoglycans are linear sulfated polysaccharides located on cell-surface membranes and in extracellular matrices in virtually all animal tissues. Heparin and HS have been implicated in cell-biological processes, cell adhesion and regulation of enzymatic catalysis (1). HS chains have been shown to interact with a variety of growth factors, chemokines, ECM proteins, and enzymes, including antithrombin, fibroblast growth factors and vascular endothelial growth factor (2). Heparin has been widely used as an anticoagulant drug (3,4), and it has been shown to regulate cellular process by binding, stabilizing and activating various growth factors (5).

    References

    1. Fritz, T. et al. (1994)  Biol. Chem.269, 28809-28814. PMID: 7759502
    2. Linhardt, R.J. et al. (1990) Biochemistry29, 2611-2617. PMID: 2334685
    3. Linhardt, R.J., and Gunay, N.S. (1999)  Thromb. Hemost. 25 Suppl 3, 5-16. PMID: 10549711
    4. Casu, B. et al. (2002) Biochemistry41, 10519-10528. PMID: 15106730
    5. Knudsen, C.B. and Knudsen, W. (2001) Cell Dev. Biol.12, 69-78. PMID: 11292372
    OUR PRODUCTS

    Heparinase I cleaves heparin, and to a lesser extent, heparan sulfate.Available as Liquid (Frozen) or Lyoplized. Click data sheets below for complete details.

    Heparinase II (EC unassigned) Heparinase II cleaves heparin and heparan sulfate. Click data sheets below for complete details.

    Heparinase III (EC 4.2.2.8) Heparinase III cleaves heparan sulfate exclusively, and does not cleave unfractionated heparin or low molecular weight heparins. Click data sheets below for complete details.