Heparinases I Applications

• In vitro neutralization of heparin in blood & plasma samples before analysis.
• Preparation of disaccharides of heparin & the preparation of oligosaccharide libraries.
• Measurement of heparin in blood & plasma using the in vitro thromboelastography (TEG) tests. • Coagulation & anticoagulation efficacy studies.
• Production of low- & ultra-low molecular weight heparins (LMWH & ULMWH) from unfractionated heparin & immobilization of heparinase I for such use.
• In-process, quality control, & compendial testing of heparins, heparan sulfate (HS), heparin- & HS-derived products.
• Structural analysis, mass spectral analysis & characterization of heparin, heparan sulfate (HS), low molecular weight heparins, & synthetic heparin pentasaccharides & oligosaccharides.
• Depolymerization of heparin, HS & chemically modified heparins, & molecular weight profiling of heparins.
• Quantification of contaminants in heparin such as over-sulfated chondroitin sulfate & persulfonated heparin & quantification of process-related impurities. • Glycobiology & cancer biology research.
• Identification of the biological properties of HS that depend on the integrity of the S-domains & determination of the spacing between S-domains.
• In vitro host-pathogen interactions in viral infections, virusadhesion inhibition studies, virus-plaque inhibition assays, cell culture experiments, etc.
• In vivo inhibition studies of neovascularization & proliferation of capillary endothelial cells.
• Circumventing the inhibitory effects of heparin in PCR, RT-PCR, real-time RT-qPCR reaction& Western Blot.
• In vitro histochemistry, immunohistochemistry, immunocytochemistry & flow cytometry, etc

IBEX Pharmaceuticals is a BBI Solutions Company. They are known for producing enzymes and other biochemicals for use in various diagnostic and therapeutic applications. One of their key products is heparinase, an enzyme that breaks down heparin, an anticoagulant widely used in medical treatments.

Heparinase Production: IBEX Pharmaceuticals is a significant producer of heparinase, which is used in laboratory settings and medical devices, particularly in assays that measure heparin levels. Heparinase can neutralize the effects of heparin in blood samples, allowing for accurate diagnostic testing.

Medical Applications: Heparinase is critical in monitoring blood coagulation during surgeries, especially cardiac surgeries, where heparin is administered to prevent clotting. It is also used in heparin monitoring devices and for research purposes in studying heparin’s effect on blood.

Quality and Expertise: IBEX has established expertise in enzyme production, and its heparinase is recognized for its purity and reliability, which is important for applications in both clinical and research settings.

Global Market: The company serves both domestic and international markets, supplying heparinase to pharmaceutical companies, medical device manufacturers, and research institutions globally.

Their leadership in heparinase production highlights IBEX Pharmaceuticals’ importance in the biotechnology and medical sectors, especially concerning heparin-related diagnostics and therapies.