Heparinase II Applications

Some known applications of Heparinase II enzyme:

  • Production of low- and ultra-low molecular weight heparins (LMWH and ULMWH)
  • Characterization of heparin, heparan sulfate (HS) and LMWH,
  • Structural analyses of heparin, HS, LMWH, heparosan and Heparin-like GAGs
  • Production and isolation of oligosaccharides with novel sequences of GlcNH3+ residues
  • Depolymerization of heparin and HS  and chemically modified heparins and molecular weight profiling of heparins and HS and chemically modified heparins
  • Quality control testing of heparin and heparin-derived products,
  • Quantification of contaminants in heparin such as over-sulfated chondroitin sulfate and persulfonated heparin
  • Quantification of process-related impurities
  • Glycobiology research,
  • In vitro host-pathogen interactions in viral infections, in vitro virus-adhesion inhibition studies, cell culture experiments
  • In vitro virus plaque inhibition assays
  • Mass spectral analysis of heparins, HS, heparin-like molecules and heparosan
  • Cancer biology research
  • In vitro immunohistochemistry, immunocytochemistry and flow cytometry
  • Circumventing the inhibitory effects of heparin in the PCR reaction, etc.

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